AlPO4 an Adjuvant

Aluminum adjuvants are used in vaccine manufacturing to “stimulate” the immune system The presence of aluminium adjuvants has been associated with injection-site reactions such as nodules, granulomas and erythema. aluminium adjuvants may lead to the syndrome macrophagic myofascitis, a histological finding where aluminium-containing macrophages infiltrate muscle tissue, and may be accompanied by a clinical syndrome of myalgia, arthralgia and fatigue. A systematic review of controlled safety studies reported that vaccines containing aluminium produce more erythema and induration than other vaccines in young children (up to 18 months of age), and greater local pain in older children (10–18 years).

Aluminum adjuvants are used in vaccine manufacturing to “stimulate” the immune system The presence of aluminium adjuvants has been associated with injection-site reactions such as nodules, granulomas and erythema. aluminium adjuvants may lead to the syndrome macrophagic myofascitis, a histological finding where aluminium-containing macrophages infiltrate muscle tissue, and may be accompanied by a clinical syndrome of myalgia, arthralgia and fatigue. A systematic review of controlled safety studies reported that vaccines containing aluminium produce more erythema and induration than other vaccines in young children (up to 18 months of age), and greater local pain in older children (10–18 years).

Animal and human studies have shown that aluminum can cause nerve cell death [1] and that vaccine aluminum adjuvants can allow aluminum to enter the brain, [2,3] as well as cause inflammation at the injection site leading to chronic joint and muscle pain and fatigue. [4,5]

EDF Suspected – cardiovascular or blood toxicant, neurotoxicant, respiratory toxicant, respiratory toxicant. Implicated as a cause of brain damage; suspected factor in Alzheimer’s Disease, dementia, convulsions and comas. More hazardous than most chemicals in 2 out of 6 ranking systems. On at least 2 federal regulatory lists. EDF Suspected – cardiovascular or blood toxicant neurotoxicant, respiratory toxicant. More hazardous than most chemicals in 3 out of 11 ranking systems. On at least 3 federal regulatory lists.

Chemical descriptions:

National Library of Medicine: PubChem
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=586133

Adverse effects
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed&term=%22Aluminum%20Hydroxide%2ftoxicity%22[Mesh%20Terms%3anoexp

Toxicity
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed&term=%22Propiolactone%2ftoxicity%22[Mesh%20Terms%3anoexp

Poisoning
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed&term=%22Aluminum%20Hydroxide%2fpoisoning%22[Mesh%20Terms%3anoexp

Scorecard: Pollution Information Site
http://www.scorecard.org/chemical-profiles/summary.tcl?edf_substance_id=7429%2d90%2d5

a.k.a. Aluminophosphoric acid, Aluminum acid phosphate, Aluminum monophosphate, Aluminum phosphate, Aluminum phosphate

 

Documentation