Yellow Fever Vaccines

//Yellow Fever Vaccines

Warning: New CDC Recommendations

The 2002 recommendations include new or updated information regarding 1) reports of yellow fever vaccine-associated viscerotropic disease (previously reported as febrile multiple organ system failure); 2) use of yellow fever vaccine for pregnant women and persons infected with human immunodeficiency virus (HIV). Note: Vaccination recommendations have recently changed.

MMWR Nov. 8, 2002 –

Yellow Fever Vaccine and Recent Reports of Associated Severe Illness

Recent reports (1-4) documented seven patients between 1996 and 2001 who developed severe illness following receipt of yellow fever vaccine (17D-204 or 17DD strains).


  1. Chan RC, Penney DJ, Little D, et al. Hepatitis and death following vaccination with 17D-204 yellow fever vaccine. Lancet 2001;358:121-2.
  2. Martin M, Tsai TF, Cropp B, Chang GJ, et al. Fever and multisystem organ failure associated with 17D-204 yellow fever vaccination: a report of four cases. Lancet 2001;358:98-104.
  3. Vasconcelos PF, Luna EJ, Galler R, et al. Serious adverse events associated with yellow fever 17DD vaccine in Brazil: a report of two cases. Lancet 2001;358:91-7
  4. Centers for Disease Control and Prevention. Notice to readers: Fever, jaundice, and multiple organ system failure associated with 17D-derived yellow fever vaccination, 1996–2001. MMWR 2001;50:343-5.

Yellow fever (also called yellow jack, black vomit or vomito negro in Spanish, or sometimes American Plague) is an acute viral disease. It is an important cause of hemorrhagic illness in some African and South American countries. Human infection is begun after deposition of viral particles through the skin in infected arthropod saliva.

Yellow fever vaccine is a live, attenuated virus preparation made from the 17D yellow fever virus strain, 17DD is used in Brazil.

Yellow Fever is Very Rare in Tourists

Yellow fever is a tropical disease that is spread to humans by infected mosquitoes and found only in Africa and South America. Fatal cases in tourists have been reported with an average of one a year for the past ten years.

There is no specific treatment for yellow fever, but most people recover after a long recovery period.


Yellow Fever Vaccines by Brand

Stamaril® Yellow fever (Live)
Manufacturer Sanofi Paseur
Microorganism Yellow fever virus
Licensed 10/13/1998
Recommendations One injection for travellors to an endemic region or preoples handling infectious matrials.
Ingredients Latex, Sorbitol, Sodium chloride, Disodium phosphate dehydrate, Lactose, Virus: Yellow fever, Potassium chloride, Monopotassium phosphate, L-histidine hydrochloride, L-alanine, Calcium chloride, Magnesium sulfate
Product Descriptions

YF –VAX® Yellow fever, live-attenuated
Manufacturer Aventis Pasteur
Microorganism Yellow fever virus, live-attenuated, 17D strain
Licensed 01/03/1978
Recommendations Single injection. Booster vaccination after 10 years.
Ingredients Gelatin, Sorbitol, Sodium chloride, Chick embryo cells, Virus: Yellow fever
Product Descriptions Package insert