Flu (influenza) Vaccines

//Flu (influenza) Vaccines
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Excerpts from:

Jefferson, T BMJ 2006;333:912-915 (28 October), Influenza vaccination: policy versus evidence http://www.bmj.com/cgi/content/full/333/7574/912

Little Safety Data Found

“In the general population of elderly people, despite a dataset of several million observations, safety was only reported in five randomised controlled trials on local and systemic adverse events seen within a week of giving parenteral inactivated vaccine… Little comparative evidence exists on the safety of these vaccines.”

Surprising Policies

“The large gap between policy and what the data tell us (when rigorously assembled and evaluated) is surprising…. Reasons for the current gap between policy and evidence are unclear, but given the huge resources involved, a re-evaluation should be urgently undertaken” Alzheimer’s Disease Caused by Flu Shots “The chances of getting Alzheimer’s Disease is ten times higher if an individual has had five consecutive flu shots between 1970 and 1980 (the years studied) than if they had one two or no shots.” — Hugh Fudenburg, M.D. Ph.D., Immunogeneticist.

Adverse Effects

Guillain-Barre syndrome, asthma, Bell’s palsy, impetigo, dermatitis, uncomplicated diabetes mellitus, ureteral disorder, etc. Review the evidence documented on this page (below) for potential consequences that can result from receiving flu shots. Evaluate the risks for yourself.

See Video

What’s in a Flu Shot (comedic)

Excerpts from:

Jefferson, T BMJ 2006;333:912-915 (28 October), Influenza vaccination: policy versus evidence http://www.bmj.com/cgi/content/full/333/7574/912

Poor Quality Studies

“Most studies are of poor methodological quality and the impact of confounders is high”

Flu Vaccine Has Little or No Effect

“In children under 2 years inactivated vaccines had the same field efficacy as placebo, and in healthy people under 65 vaccination did not affect hospital stay, time off work, or death from influenza and its complications… Evidence from systematic reviews shows that inactivated vaccines have little or no effect on the effects measured.”

“Surprising” Policies

“The large gap between policy and what the data tell us (when rigorously assembled and evaluated) is surprising…. Reasons for the current gap between policy and evidence are unclear, but given the huge resources involved, a re-evaluation should be urgently undertaken”

Mutating Strains

The flu virus mutates (changes it’s structure) yearly. It’s guesswork to produce a vaccine during the previous year against strains which might be prevalent during the next year’s “flu season”

Benign Disease Not Worthy of Intervention

Influenza, commonly known as the flu, is an infectious disease of birds and mammals caused by an RNA virus of the family Orthomyxoviridae (the influenza viruses). It’s effects are largely temporary and mild.

Flu is MUCH more Benign Than Government Numbers Show

The figure of “36,000 Americans Die Annually From Influenza” has been repeated by public health officials like a mantra and it gets parroted throughout the media as fact. Journalists do not seem to care that it has no source.

Turns out, this figure’s origins cannot be found. Nowhere was there a published study explaining or confirming a “36,000 deaths” figure. We looked.

We found the testimony of CDC Director Julie L. Gerberding, MD, on Feb. 12, 2004, who stated that “CDC scientists estimate that an average of 36,000 people die from influenza-related complications each year in the United States.”(1) but no publication is referenced and we can find no publication that states anywhere near this number.

Then we found the raw data from the CDC that tells exactly how many deaths occur annually due from influenza and influenza-related complications, and even these are unconfirmed by viral cultures.

National Vital Statistics Reports. Deaths: Preliminary Data for 2003, Volume 53 Number 15 2003 Deaths from influenza = 1.805 http://origin.cdc.gov/nchs/data/nvsr/nvsr53/nvsr53_15.pdf (p.16)

National Vital Statistics Reports. Deaths: Final Data for 2002, Volume 53 Number 5 2002 Deaths from influenza = 747 http://www.cdc.gov/nchs/data/nvsr/nvsr53/nvsr53_05.pdf (p.31)

National Vital Statistics Reports. Deaths: Final Data for 2001, Volume 52 Number 3 2001 Deaths from infleunza = 257 http://www.cdc.gov/nchs/data/nvsr/nvsr52/nvsr52_03.pdf (p.31)

National Vital Statistics Reports. Deaths: Final Data for 2000, Volume 50 Number 15 2000 Deaths from infleunza = 1,765 http://www.cdc.gov/nchs/data/nvsr/nvsr50/nvsr50_15.pdf (p.29)

National Vital Statistics Reports. Deaths: Final Data for 1999, Volume 49 Number 8. 1999 Deaths from influenza = 1,665 http://www.cdc.gov/nchs/data/nvsr/nvsr49/nvsr49_08.pdf (p28)

Using the figures for the past five years available reports, the average annual death toll form influenza is almost 1,248. 36,000 deaths may sound much scarier, but it’s not rooted in science or fact. Likely, it’s a publicity thing and they know.

Flu (influenza) Vaccines by Brand

Afluria flu (influenza) vaccine
Manufacturer CSL Biotherapies
Microorganism influenza virus
Licensed 09/28/2007
Recommendations One intramuscular injection.
Ingredients Beta-propiolactone, Neomycin, Polymyxin B, Sucrose, Thimerosal, Mercury, Sodium phosphate-monobasic, Chick embryo cells, Potassium chloride, Neomycin sulphate, Calcium chloride, Sodium deoxycholate, Sodium phosphate- dibasic anhydrous, Potassium phosphate- monobasic
Product Descriptions Package insert

Begrivac Influenza vaccine (split virion, inactivated)
Manufacturer Wyeth
Microorganism Influenza Virus
Licensed 08/13/1998
Recommendations From children 6 months and older, one i.m. injection, size of dose smaller for 6-36 months, booster dose recommended for children who have not previously been vaccinated.
Ingredients Formaldehyde, Polymyxin B, Polysorbate 80, Sucrose, Sodium chloride, Potassium dihydrogen phosphate, Disodium phosphate dehydrate, Potassium chloride, Egg protein, Virus: Influenza virus antigens, Magnesium chloride hexahydrate, Diethylether
Product Descriptions emc medicine guide

Enzira Influenza vaccine (split virion, inactivated)
Manufacturer CSL
Microorganism Influenza Virus
Licensed 04/19/2005
Recommendations Adults and children from 36 months, children from 6 to 36 months at a reduced dosage, second dose should be given for children that are previously unvaccinated
Ingredients Sodium chloride, Potassium dihydrogen phosphate, Potassium chloride, Sodium dihydrogen phosphate dehydrate, Egg protein, Calcium chloride, Virus: Influenza, Anhydrous disodium phosphate
Product Descriptions

Fluad® Influenza Vaccine
Manufacturer Chiron
Microorganism Influenza Virus
Licensed (EU)
Recommendations
Ingredients Squalene, MF59
Product Descriptions

Fluarix® Influenza Virus Vaccine
Manufacturer GlaxoSmithKline
Microorganism Influenza Virus
Licensed 08/31/2005
Recommendations Not for use in children. Single dose for adults.
Ingredients Formaldehyde, Gentamicin Sulfate, Latex, Polysorbate 80, Thimerosal, Ovalbumin (egg), Egg protein, Influenza A virus hemagglutinin, Influenza B virus hemagglutinin, Octoxynol-10, alpha-tocopheryl, Hydrogen succinate, Hydrocortisone, Sodium deoxycholate
Product Descriptions

FluLaval Influenza Virus Vaccine
Manufacturer GlaxoSmithKline
Microorganism Influenza strains A/New Caledonia/20/99 (H1N1), 15 mcg; A/Wisconsin/67/2005 (H3N2), 15 mcg; B/Malaysia/2506/2004
Licensed 10/05/2006
Recommendations Age 18 or older, single injection.
Ingredients Formaldehyde, Thimerosal, Mercury, Egg protein, Influenza A virus hemagglutinin, Influenza B virus hemagglutinin, Sodium deoxycholate
Product Descriptions Prescribing Information

FluMist® Live, intranasal influenzae
Manufacturer MedImmune, Wyeth
Microorganism H1N1, H3N2, B/Jilin/20/2003 (B/Shanghai/361/2002-13 like strains of Influenza virus
Licensed 01/05/2007
Recommendations Ages 2-49
Ingredients Gentamicin Sulfate, Monosodium Glutamate (MSG), Sucrose, Potassium phosphate
Product Descriptions

Fluvax Inactivated Influenza Vaccine (Split Virion)
Manufacturer CSL Limited
Microorganism Influenza virus H1N1, H3N2, B/Malaysia/2506/2004 strains
Licensed
Recommendations One injection yearly, from three months of age with differing strengths according to age.
Ingredients Neomycin, Polymyxin B, Sucrose, Sodium chloride, Sodium phosphate-monobasic, Potassium chloride, Egg protein, Virus: Influenza, Sodium phosphate- dibasic anhydrous, Potassium phosphate- monobasic, Sodium taurodeoxycholate
Product Descriptions Package insert

Fluviral, Fluviral S/F Influenza Virus Vaccine Trivalent, Inactivated Whole-Virion Active Immunizing Agent
Manufacturer Shire (Canada)
Microorganism Influenza virus H1N1, H3N2, B/Malaysia/2506/2004 strains
Licensed
Recommendations Annually in the fall. Children under 9 years of age require two injections one month apart, the first time they have the vaccine. Differing dosages for different age groups, from 6 months up.
Ingredients Formaldehyde, Thimerosal, Egg protein, Virus: Influenza, Sodium deoxycholate, Triton X-100
Product Descriptions

Fluvirin® Purified Surface Antigen Vaccine, Trivalent, Types A and B
Manufacturer Chiron Corporation
Microorganism Influenza virus H1N1, H3N2, B/Malaysia/2506/2004 strains
Licensed 07/21/2006
Recommendations Not for use for patients under four years of age: 1 or 2 injections for those 4 to 8 years of age, one injection for those 9 years of age or older.
Ingredients Neomycin, Polymyxin B, Thimerosal, Egg protein, Triton N101, M phosphate- buffered saline
Product Descriptions Package insert

Fluzone® influenza virus vaccine trivalent, inactivated
Manufacturer Aventis Pasteur
Microorganism Influenza virus types A and B — A/New Caledonia/20/99, A/Wyoming/03/2003 (an A/Fujian/411/2002-like, B/Jiangsu/10/2003 (a B/Shanghai/361/2002-like) strains
Licensed 07/10/2006
Recommendations One or two i.m. injections for those 6 months of age or older, (reduced potency for age 6 to 35 months).
Ingredients Formaldehyde, Gelatin, Latex, Thimerosal, Egg protein, Virus: Influenza
Product Descriptions

Focetria® Pandemic influenza vaccine
Manufacturer Novartis
Microorganism influenza virus
Licensed 5/8/2007 (EU)
Recommendations
Ingredients Squalene, Virus: Influenza, MF59
Product Descriptions

Grippol Vaccination for flu prevention three-valence polymer-sub-single liquid
Manufacturer Institute of Immunology
Microorganism influenza virus
Licensed
Recommendations Children from 6 months, 3 doses with four week intervals; over 3 years, one dose.
Ingredients Virus: Influenza, Superficial glycoproteins (gemagglutinin and neyroamynidasa), Polyoxidonium, Hemagglutinin culture flu viruses of type A(H1N1), A(H3N2)
Product Descriptions

Inflexal, Inflexal S, Inflexal V Influenza vaccine (surface antigen, inactivated, virosomic)
Manufacturer Sanofi Pasteur
Microorganism influenza virus
Licensed 03/29/2005
Recommendations From six months, higher dosage for those over 3 years of age.
Ingredients Sodium chloride, Egg protein, Virus: Influenza, Disodium dehydrogenate phosphate, Potassium dehydrogenate phosphate, Lecithin
Product Descriptions http://www.crucell.com/Products-Inflexal_V

Influvac Influenza vaccine, surface antigen, inactivated
Manufacturer Solvay-Pharma
Microorganism influenza virus
Licensed 07/15/2005
Recommendations Adults, elderly, and children over 36 months, single injection.
Ingredients Formaldehyde, Sodium chloride, Potassium dihydrogen phosphate, Disodium phosphate dehydrate, Potassium chloride, Egg protein, Calcium chloride, Magnesium chloride hexahydrate, Virus: Influenza
Product Descriptions Package insert

Mastaflu influenza vaccine, surface antigen, inactivated
Manufacturer Solvay
Microorganism influenza virus
Licensed
Recommendations adults and children from 36 months, single dose.
Ingredients Sodium chloride, Potassium dihydrogen phosphate, Disodium phosphate dehydrate, Potassium chloride, Egg protein, Calcium chloride, Magnesium chloride hexahydrate, Virus: Influenza
Product Descriptions

Mutagrip  Influenza Vaccine (SPLIT VIRION)
Manufacturer Aventis
Microorganism influenza virus
Licensed 08/28/1998
Recommendations Single 0.5 mL i.m. injection for those 36 months of age and older.
Ingredients Sodium chloride, Disodium phosphate dehydrate, Potassium chloride, Monopotassium phosphate, Egg protein, Virus: Influenza
Product Descriptions

Optaflu
Manufacturer Novartis
Microorganism influenza virus
Licensed 06/13/2007 (EU)
Recommendations One intramuscular injection, seasonally.
Ingredients Dog kidney cells
Product Descriptions

Vaxigrip Inactivated Influenza Vaccine Trivalent Types A and B (Split Virion)
Manufacturer Sanofi Pasteur
Microorganism influenza virus
Licensed 09/28/2007
Recommendations 6 months of age or older.
Ingredients Formaldehyde, Neomycin, Sucrose, Thimerosal, Sodium phosphate, Virus: Influenza, Triton X-100
Product Descriptions Package insert