Cholera Vaccines

//Cholera Vaccines
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Cholera is a water-borne disease caused by the bacterium Vibrio cholerae, which is typically ingested by drinking contaminated water, or by eating improperly cooked fish, especially shellfish. The disease is mostly seen in Third World countries, due to poor water infrastructure.

About one million V. cholerae bacteria must be ingested to cause cholera in normally healthy adults, although increased susceptibility may be observed in those with a weakened immune system, individuals with decreased gastric acidity (as from the use of antacids), or those who are malnourished.

Cholera is then transmitted through ingestion of feces contaminated with the bacterium. The contamination usually occurs when untreated sewage is released into waterways or into groundwater, affecting the water supply, any foods washed in the water, and shellfish living in the affected waterway — it is rarely spread directly from person to person.

These facts beg the question: instead of spending untold millions of dollars on vaccine research, development, manufacturing, marketing and implementation – why not just improve the poor people’s sanitation and water supply?

Cholera is a water-borne disease caused by the bacterium Vibrio cholerae, which is typically ingested by drinking contaminated water, or by eating improperly cooked fish, especially shellfish. The disease is mostly seen in Third World countries, due to poor water infrastructure. About one million V. cholerae bacteria must be ingested to cause cholera in normally healthy adults, although increased susceptibility may be observed in those with a weakened immune system, individuals with decreased gastric acidity (as from the use of antacids), or those who are malnourished.

Cholera is then transmitted through ingestion of feces contaminated with the bacterium. The contamination usually occurs when untreated sewage is released into waterways or into groundwater, affecting the water supply, any foods washed in the water, and shellfish living in the affected waterway — it is rarely spread directly from person to person.

These facts beg the question: instead of spending untold millions of dollars on vaccine research, development, manufacturing, marketing and implementation – why not just improve the poor people’s sanitation and water supply?

Cholera Vaccines by Brand

Mutacol® Oral, live attenuated cholera vaccine, CVD 103-HgR
Manufacturer Berna, Switzerland Division
Microorganism Cholera, specifically 01 V. cholerae
Licensed
Recommendations Adults and children aged > 6 years: 2 doses at intervals of at least 1 week but not greater than 6 weeks. Children aged 2 to 6 years: 3 doses at least 1 week apart but not greater than 6 weeks apart.
Ingredients Sodium bicarbonate, Sucrose, Lactose, Amino acids, Ascorbic acid, Casamino acids (casein), Yeast extract, Mineral salts, Aspartame
Product Descriptions

Dukoral Live, oral cholera
Manufacturer SBL Vaccin AB (Sweden), imported and distributed by Aventis Pasteur (Canada)
Microorganism The bacteria Vibrio Cholerae serogroup 01
Licensed 03/05/2004
Recommendations 2 doses for adults and children from 6 years of age. Children 2-6 years of age should receive 3 doses. Doses are to be administered at intervals of at least one week. If more than 6 weeks have elapsed between doses, the primary immunization course should be re-started.
Ingredients
Product Descriptions Product Summary

CholeraGarde®
Manufacturer CholeraGarde-Avant Immunotherapeutics, Inc
Microorganism Vibrio cholerae
Licensed Not licensed. Under development
Recommendations Under development
Ingredients
Product Descriptions